![]() The gold standard for diagnosing SIBO is still microbial investigation of jejunal aspirates. Symptoms related to SIBO are bloating, diarrhoea, malabsorption, weight loss and malnutrition. In some patients more than one factor may be involved. scleroderma, autonomic neuropathy in diabetes mellitus, post-radiation enteropathy, small intestinal pseudo-obstruction). small intestinal obstruction, diverticula, fistulae, surgical blind loop, previous ileo-caecal resections) and/or motility disorders (e.g. achlorhydria, pancreatic exocrine insufficiency, immunodeficiency syndromes), anatomical abnormalities (e.g. Aetiology of SIBO is usually complex, associated with disorders of protective antibacterial mechanisms (e.g. There are several endogenous defence mechanisms for preventing bacterial overgrowth: gastric acid secretion, intestinal motility, intact ileo-caecal valve, immunoglobulins within intestinal secretion and bacteriostatic properties of pancreatic and biliary secretion. SIBO is defined as an increase in the number and/or alteration in the type of bacteria in the upper gastrointestinal tract. Any dysbalance of this complex intestinal microbiome, both qualitative and quantitative, might have serious health consequence for a macro-organism, including small intestinal bacterial overgrowth syndrome (SIBO). This is characterised by its high population density, wide diversity and complexity of interaction. ![]() Human intestinal microbiota create a complex polymicrobial ecology.
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